Valsartan and Hydrochlorothiazide, USP is indicated for the treatment of hypertension.
It may be used in patients whose blood pressure is not adequately controlled on monotherapy.
It may be used as initial therapy in patients who are likely to need multiple drugs to achieve blood pressure goals. The choice of Valazyd H as initial therapy for hypertension should be based on an assessment of potential benefits and risks.
Patients with stage 2 hypertension are at a relatively high risk for cardiovascular events (such as strokes, heart attacks, and heart failure), kidney failure, and vision problems, so prompt treatment is clinically relevant. The decision to use a combination as initial therapy should be individualized and should be shaped by considerations such as baseline blood pressure, the target goal and the incremental likelihood of achieving goal with a combination compared to monotherapy. Individual blood pressure goals may vary based upon the patient' risk.
Data from the high dose multifactorial trial provides estimates of the probability of reaching a target blood pressure with Valazyd H compared to valsartan or hydrochlorothiazide monotherapy.
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