IV infusion over 30 min.
Adult 3.375 g every 6 hr.
Nosocomial pneumonia Piperacillin 16 g + tazobactam 2 g. Continue treatment w/ aminoglycoside if
Pseudomonas aeruginosa isolated. To be given 7-14 days.
Community-acquired pneumonia, intra-abdominal infections (appendicitis &/or peritonitis), uncomplicated & complicated UTI, skin & skin structure infections, pelvic inflammatory disease Childn >40 kg 4.5 g every 6 hr,
≥9 mth or up to 40 kg Piperacillin 100 mg + tazobactam 12.5 mg per kg every 8 hr or 3.375 g every 6 hr + aminoglycoside,
2 mth & 9 mth Piperacillin 80 mg + tazobactam 10 mg per kg every 8 hr.
Renal impairment CrCl >40 mL/min 3.375 g every 6 hr,
20-40 mL/min 2.25 g every 6 hr,
<20 mL/min & patient not receiving dialysis 2.25 g every 8 hr.
Patient on hemodialysis 2.25 g every 12 hr. Additional dose of 0.75 g should be administered following each dialysis period on hemodialysis days.
Patient on CAPD 2.25 g every 12 hr or 8 hr.
Nosocomial pneumonia CrCl >40 mL/min 4.5 g every 6 hr,
20-40 mL/min 3.375 g every 6 hr,
<20 mL/min & patient not receiving dialysis 2.25 g every 6 hr.
Patient on hemodialysis 2.25 g every 8 hr. Additional dose of 0.75 g should be administered following each dialysis period on hemodialysis days.
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