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Oral: With oral administration, the undesirable effects described in Adverse Reactions are mostly symptomatic of overdosage.
A reduction in dosage will cause such signs to regress spontaneously.
In some users, the usual dosage may prove to be too high, as evidenced by the persistence or recurrence of uncontrolled endogenous progesterone secretion, marked sensitivity to the product itself or concomitantly low levels of blood oestradiol. The following measures should be taken: Progesterone should be administered in the evening AT BEDTIME, over a 10-day period per cycle.
In the event of breakthrough bleeding (spotting)/shortening of the menstrual cycle, initiation of treatment should be deferred until later into the cycle (e.g. day 19 instead of day 17).
Perimenopausal women/women receiving HRT should be tested to ensure that blood oestradiol levels are sufficient.
Vaginal: With vaginal administration, no case of overdose has so far been reported.
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