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As a single agent, a usual dose by intravenous injection is 12 mg per kg body-weight daily (to a maximum of 0.8 to 1 g daily) for 3 or 4 days. If there is no evidence of toxicity, this may be followed after 1 day by 6 mg per kg on alternate days for 3 or 4 further doses. An alternative schedule is to give 15 mg per kg intravenously once a week throughout the course. The course may be repeated after 4 to 6 weeks or maintenance doses of 5 to 15 per kg (up to a maximum of 1 g) may be given weekly.
Fluorouracil may also be given by intravenous infusion, usual doses of 15 mg per kg daily (to a maximum of 1 g daily) being infused in 500 mL of 0.9% sodium chloride or 5% glucose injection over 4 hours and repeated on successive days until toxicity occurs or a total of 12 to 15 g has been given. Continuous infusion may also be used. The course may be repeated after 4 to 6 weeks. Fluorouracil has also been given by continuous intra-arterial infusion in doses of 5 to 7.5 mg per kg daily (regional perfusion).
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