Twynsta Overdosage

Symptoms: There is no experience of overdose with Telmisartan + Amlodipine besilate (TWYNSTA). Signs and symptoms of overdose are expected to be in line with exaggerated pharmacological effects.
The most prominent manifestations of telmisartan overdosage were hypotension, tachycardia; bradycardia also occurred.
Overdose with amlodipine may result in excessive peripheral vasodilation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to and including shock with fatal outcome may occur.
Non-cardiogenic pulmonary oedema has rarely been reported as a consequence of amlodipine overdose that may manifest with a delayed onset (24-48 hours post-ingestion) and require ventilatory support. Early resuscitative measures (including fluid overload) to maintain prefusion and cardiac output may be precipitating factors.
Therapy: If symptomatic hypotension should occur, supportive treatment should be instituted.
Intravenous calcium gluconate may be beneficial in reversing the effects of calcium channel blockade.
Gastric lavage may be worthwhile in some cases. In healthy volunteers the use of charcoal up to 2 hours after administration of amlodipine 10 mg has been shown to reduce the absorption rate of amlodipine.
Telmisartan is not removed from blood by hemofiltration and is not dialyzable. Amlodipine is not dialyzable.