Triveram Initio/Triveram Drug Interactions

Patient should tell the doctor if taking, have recently taken or might take any other medicines.
Atorvastatin + Perindopril arginine + Amlodipine (Triveram) may affect or be affected by other medicines, such as: immunosuppressants (medicines which reduce the defense mechanism of the body) used for the treatment of auto-immune disorders or following transplant surgery (e.g. ciclosporin, tacrolimus), ketoconazole, itraconazole, voriconazole, fluconazole, posa­conazole (anti-fungal medicines), rifampicin, erythromycin, clarithromycin, telithromycin, fusidic acid*, trimethoprim (antibiotics for infection caused by bacteria), colchicine (used in the treatment of gout, a disease with painful, swollen joints caused by uric acid crystals), other medicines to regulate lipid levels, e.g. gemfibrozil, other fibrates, colestipol, ezetimibe, some calcium channel blockers used for angina or high blood pressure, e.g. diltiazem, medicines to regulate the heart rhythm e.g. digoxin, verapamil, amiodarone, medicines used in the treatment of HIV or liver disease such as Hepatitis C e.g. delavirdine, efavirenz, ritonavir, lopinavir, atazanavir, indinavir, darunavir, telaprevir, boceprevir and the combination of elbasvir/grazoprevir, warfarin (which reduces blood clotting), oral contraceptives, stiripentol (an anti-convulsant for epilepsy), cimetidine (used for heartburn and peptic ulcers), phenazone (a painkiller), antacids (indigestion products containing aluminium or magnesium), medicine obtained without a prescription Hypericum pertoratum or St John's Wort (herbal treatment used for depression), dantrolene (infusion for severe body temperature abnormalities), other medicines for high blood pressure, including aliskiren, angiotensin II receptor blockers (e.g. valsartan), see also information under Contraindications and Precautions, potassium-sparing drugs (e.g. triamterene, amiloride, eplerenone, spironolactone), potassium supplements or potassium-containing salt substitutes, other drugs which can increase potassium in the body (such as heparin and co-trimoxazole also known as trimethoprim/sulfamethoxazole), estramustine (used in cancer therapy), lithium for mania or depression, medicines, which are most often used to treat diarrhea (racecadotril) or avoid rejection of transplanted organs (sirolimus, everolimus, temsirolimus and other drugs belonging to the class of so-called mTor inhibitors). See Precautions, medicines used to treat diabetes (such as insulin, metformin or gliptines), sacubitril/valsartan (used to treat long-term heart failure), baclofen (used to treat muscle stiffness in diseases such as multiple sclerosis), non-steroidal anti-inflammatory drugs (e.g. ibuprofen) for pain relief or treatment of inflammation (e.g. in case of rheumatoid arthritis) or high dose aspirin, vasodilators including nitrates (products that make the blood vessels become wider), medicines to treat mental disorders such as depression, anxiety, schizophrenia, etc. (e.g. tricyclic antidepressants, antipsychotics), medicines used for the treatment of low blood pressure, shock or asthma (e.g. ephedrine, noradrenaline or adrenaline), gold salts, especially with intravenous administration (used to treat symptoms of rheumatoid arthritis), allopurinol (for the treatment of gout), procainamide (for the treatment of an irregular heart beat).
*If the patient needs to take oral fusidic acid to treat a bacterial infection they will need to temporarily stop using Triveram. The doctor will tell the patient when it is safe to restart Triveram. Taking Triveram with fusidic acid may rarely lead to muscle weakness, tenderness or pain (rhabdomyolysis).
Grapefruit and grapefruit juice: Grapefruit juice and grapefruit should not be consumed by people who are taking Atorvastatin + Perindopril arginine + Amlodipine (Triveram). This is because grapefruit and grapefruit juice can lead to an increase in the blood levels of the active ingredient amlodipine, which can cause an unpredictable increase in the blood pressure lowering effect of this medicine.
If taking this medicine, do not take more than one or two small glasses of grapefruit juice per day because large quantities of grapefruit juice will lead to an increased effect of the active ingredient atorvastatin.
Alcohol: Avoid drinking too much alcohol while taking this medicine.