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Pharmacology: Pharmacodynamics: In patients with ischemic heart disease, Trimetazidine acts as a metabolic agent, preserving the myocardial high-energy phosphate intracellular levels. Anti-ischemic effects are achieved without concomitant hemodynamic effects.
Pharmacokinetics: Trimetazidine after oral administration, absorption of Trimetazidine is rapid and the plasma peak is reached in less than 2 hours. After a single oral dose of 35 mg of Trimetazidine, the peak plasma concentration is about 55 mg/mL. The apparent volume of distribution is 4.8 L/kg which suggests good tissue diffusion. Elimination of Trimetazidine is principally urinary; mean half-life is 6 hours.
