Triobees Mechanism of Action

Pharmacology: Thiamine is important for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. It is needed to maintain the health of the nerves and the heart. It combines with adenosine triphosphate (ATP) to form a coenzyme, thiamine pyrophosphate or cocarboxylase which is necessary for carbohydrate metabolism.
Pyridoxine is converted into its active form, pyridoxal 5'-phosphate (PLP), an essential cofactor in many enzymatic activities including synthesis of amino acids, neurotransmitters (serotonin, dopamine, norepinephrine and GABA), and sphingolipids.
Cyanocobalamin combines with an intrinsic factor for absorption in the intestine. It is necessary for hematopoiesis, neural metabolism, DNA and RNA production, and carbohydrate, fat, and protein metabolism. It is vital for myelin sheath formation which protects the nerve fiber and influences the speed of signal transmission.
Pharmacokinetics: Thiamine is absorbed from the GI tract and is widely distributed to most body tissues. It is not stored to any appreciable extent in the body and amounts in excess of requirements are excreted in the urine as unchanged thiamine or metabolites.
Pyridoxine is absorbed from the GI tract and is converted to the active form pyridoxal phosphate. It is stored mainly in liver with lesser amounts in muscle and brain. It also crosses the placenta and is distributed into milk. It is excreted in the urine as 4-pyridoxic acid.
Cyanocobalamin is irregularly absorbed from the distal small intestine following oral administration. It requires gastric intrinsic factor for active absorption from the GI tract. It is distributed into liver, bone marrow, and other tissues. It also crosses the placenta and is distributed into milk. More than 50-98% may be excreted in urine.