Trimic Special Precautions

Caution should be taken while administering TRIMIC (Metronidazole + Miconazole Nitrate) vaginal suppositories to patients with liver impairment including porphyria, diseases of the nervous system and hematopoiesis.
Pessaries may be used after the first trimester of pregnancy in cases considered essential by a physician, but should be used under control. Breastfeeding should be discontinued during Trimic therapy, since metronidazole appears in milk. Breastfeeding can be started again 24-48 hours after the end of therapy. Patients should be warned not to take alcohol during the therapy and for at least 2 days after the end of a course of treatment because of the possibility of disulfiram-like reactions. The base contained in the pessary formulation may interact with certain rubber or latex products, such as those used in vaginal contraceptive diaphragms or condoms, therefore, concurrent use is not recommended. Sexual partners of patients with Trichomonas vaginalis should be treated at the same time.