Adult 1-2 g daily as single or in 2 divided doses. Severe infections Up to 4 g daily. Surgical infection prophylaxis 1 g single dose 0.5-2 hr prior to surgery. Gonorrhea 250 mg IM as a single dose. Childn Serious infections other than CNS infections (meningitis) 50-75 mg/kg daily in equally divided doses every 12 hr or in single daily doses. Max: 2 g. CNS infections 100 mg/kg in equally divided doses every 12 hr or 75 mg/kg as a loading dose to initiate therapy. Hepatic dysfunction & significant renal disease 2 g daily. Usual duration of therapy: 4-14 days.
Hypersensitivity to cephalosporins &/or penicillins. GI disease especially collitis. Altered prothrombin. Discontinue in patients showing evidence of gall bladder disease or sonographic abnormalities. Pregnancy & lactation.
Diarrhea, occasional nausea/vomiting, glossitis or stomatitis; hypersensitivity reactions (eg, rash, pruritus, urticaria & edema), transient pain at site of IM inj & local phlebitis.
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