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Patients with acute alcohol intoxication.
Patients with intoxication of drugs which act on the central nervous system, such as hypnotics, analgesics, or psychotic drugs.
Patients with severe respiratory depression especially in the presence of cyanosis and on excessive bronchial secretion.
Patients with a risk of stupor due to head injuries or head lesions.
Patients receiving MAO inhibitors.
Patients with condition in which intracranial pressure is raised.
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