Sign Out
Signs and symptoms: Overdoses of Topiramate have been reported. Signs and symptoms included convulsions, drowsiness, speech disturbances, blurred vision, diplopia, impaired mentation, lethargy, abnormal coordination, stupor, hypotension, abdominal pain, agitation, dizziness and depression. The clinical consequences were not severe in most cases, but deaths have been reported after overdoses with multiple medicinal products including Topiramate.
Topiramate overdose can result in severe metabolic acidosis (see Precautions).
Treatment: In the event of overdose, Topiramate should be discontinued and general supportive treatment given until clinical toxicity has been diminished or resolved. The patient should be well hydrated. Hemodialysis has been shown to be an effective means of removing Topiramate from the body. Other measures may also be taken at the physician's discretion.
