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Each ml contains: Irinotecan Hydrochloride Trihydrate 20 mg, Sorbitol USP 45 mg, Lactic Acid USP 0.9 mg, Water for Injection USP q.s.
TOPOBLOCK (Irinotecan Hydrochloride Injection) is an antineoplastic agent of topoisomerase I inhibitor class. Irinotecan hydrochloride was clinically investigated as CPT-II. It is supplied as a clear colorless to light pale yellow solution. Irinotecan is intended for dilution with 5% Dextrose injection (USP) or 0.9% sodium-chloride injection (USP) prior to intravenous infusion.
The preferred diluent is 5% dextrose injection (USP).
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