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Tidomet 100 mg/25 mg and Tidomet CR: Pyridoxine may reverse some effects of levodopa but its value in overdosage has not been established; it does not reverse the effects of levodopa given with peripheral dopa-carboxylase inhibitor.
Tidomet 250 mg/25 mg: Pyridoxine is not effective in reversing the actions of co-careldopa. General supportive measures should be employed along with immediate gastric lavage. Intravenous fluids should be administered judiciously and adequate airway maintained. ECG monitoring should be instituted if patient develops arrhythmias. If required appropriate antiarrythmics should be administered.
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