Adverse effects have been reported to be usually mild and transient, and include dizziness and dose related orthostatic hypotension. Hypotension may occur particularly in patient with volume depletion (for example those who have received high-dose diuretics). Impaired renal function and rarely, rash, angioedema and raised liver enzyme values may occur. Hyperkalaemia and myalgia have been reported less likely than ACE inhibitors to cause cough. Other adverse effect that have been reported with angiotensin II receptor antagonists include respiratory tract disorders, back pain, gastrointestinal disturbances, fatigue, and neutropenia. Adverse effects frequently experienced with hydrochlorothiazide include electrolyte imbalances, glycosuria, hyperglycaemia, hyperuricemia and weakness. Other side effects include gastrointestinal disturbances, headaches, dizziness, photosensitivity, reactions, postural, hypotension, paraesthesia, importance, xanthene, xanthopsia, hypersensitivity, cholestatic jaundice, pancreatitis and blood dyscrasias. The hypokalemia produced by hydrochlorothiazide.