Telxibloc Drug Interactions

Telmisartan: Digoxin: When Telmisartan was co-administered with Digoxin, medial increases in Digoxin peak plasma concentration (49%) and in trough concentration (20%) were observed.
Monitoring of digoxin levels is recommended when initiating, adjusting, and discontinuing Telmisartan to avoid possible over-or under-digitalization.
Warfarin: Telmisartan administered for 10 days with warfarin slightly decreased the mean warfarin trough plasma concentration without a change in International Normalized Ratio (INR).
Other Drugs: Co-administration of Telmisartan did not result in a clinically significant interaction with Acetaminophen, Amlodipine, Glibenclamide, Simvastatin, Hydrochlorothiazide or Ibuprofen. Telmisartan is not metabolized by the cytochrome P450 system and had no effects in vitro on cytochrome P450 enzymes, except for some inhibition of CYP2C19. Telmisartan is not expected to interact with drugs that inhibit or are metabolized by cytochrome P450 enzymes, except for possible inhibition of the metabolism of drugs metabolized by CYP2C19.
Hydrochlorothiazide: When administered concurrently, the following drugs may interact with thiazide diuretics: Alcohol, Barbiturates, or Narcotics: Potentiation of orthostatic hypotension may occur.
Antidiabetic Drugs (Oral Agents and Insulin): Dosage adjustment of the antidiabetic drug may be required.
Other Antihypertensive Drugs: Additive effect or potentiation.
Cholestyramine and Colestipol Resins: Absorption of Hydrochlorothiazide is impaired in the presence of anionic exchange resins. Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85% and 43%, respectively.
Corticosteroids, ACTH: Intensified electrolyte depletion, particularly hypokalemia.
Pressor Amines (eg, Norepinephrine): Possible decreased response to pressor amines but not sufficient to preclude their use.
Skeletal Muscle Relaxants, Non-Depolarizing (eg, Tubocurarine): Possible increased responsiveness to the muscle relaxant.
Lithium: Should not generally be given with diuretics. Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): In some patients, the administration of a NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, when Hydrochlorothiazide and NSAIDs are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.