Administer by IV infusion over 30 min. Adult Usual total daily dose: 3.375 g every 6 hr totaling 13.5 g (piperacillin 12 g/tazobactam 1.5 g). Childn w/ appendicitis &/or peritonitis ≥9 mth, up to 40 kg, & w/ normal renal function Piperacillin 100 mg/tazobactam 12.5 mg/kg every 8 hr. Childn 2-9 mth Piperacillin 80 mg/tazobactam 10 mg/kg every 8 hr. Childn >40 kg & w/ normal renal function Adult dose. All indicationRenal impairment CrCl >40 mL/min 3.375 g every 6 hr, 20-40 mL/min 2.25 every 6 hr, <20 mL/min 2.25 g every 8 hr, hemodialysis 2.25 g every 12 hr. An additional dose of 0.75 g should be administered following each dialysis period on hemodialysis days, CAPD 2.25 g every 12 hr.
Serious & occasionally fatal hypersensitivity (anaphylactic/anaphylactoid) reactions (including shock). Severe cutaneous adverse reactions eg, SJS, TEN, DRESS, & acute generalized exanthematous pustulosis. Discontinue use if an allergic reaction or bleeding manifestation occurs; hemophagocytic lymphohistiocytosis is suspected. Nephrotoxicity in critically ill patients. Clostridioides difficile-associated diarrhea. Development of drug resistant bacteria. Patients requiring restricted salt intake. Closely monitor patients who develop skin rash & discontinue use if lesions progress; patients w/ renal impairment or seizure disorders for signs & symptoms of neuromuscular excitability or seizures. Perform periodic assessment of hematopoietic function, especially w/ prolonged therapy ie, ≥21 days; periodic electrolyte determinations in patients w/ low K reserves. Concomitant use w/ vancomycin. Pregnancy & lactation.
May be associated w/ increased incidence of acute kidney injury w/ vancomycin. Substantial inactivation of aminoglycosides. Modest decreases in serum conc of tobramycin. Prolonged t1/2 w/ probenecid. Concomitant use w/ high doses of heparin, oral anticoagulants, or other drugs that may affect blood coagulation system or the thrombocyte function. Prolonged neuromuscular blockade of vecuronium. May reduce clearance of MTX.
J01CR05 - piperacillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
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