Tamplus Drug Interactions

Finasteride: No clinically important drug interactions have been identified. Finasteride does not appear to significantly affect the cytochrome P450-linked drug metabolizing enzyme system. Compounds which have been tested in man include propranolol, digoxin, glibenclamide, warfarin, theophylline, and antipyrine and no clinically meaningful interactions were found. Although specific interaction studies were not performed in clinical studies, Finasteride was used concomitantly with ACE inhibitors, alpha-blockers, beta-blockers, calcium channel blockers, cardiac nitrates, diuretics, H2 antagonists, HMG-CoA reductase inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin and paracetamol, quinolones and benzodiazepines without evidence of clinically significant adverse interactions.
Tamsulosin: No clinically significant effects on blood pressure or pulse rate were observed when tamsulosin was given concomitantly with atenolol, enalapril, nifedipine or theophylline. Concomitant administration of cimetidine increases plasma levels of tamsulosin. Concomitant administration of furosemide reduces plasma levels of Tamsulosin. Plasma levels of tamsulosin however remain within the normal range when used together with furosemide or cimetidine. In vitro, neither diazepam, propranolol, trichlormethiazide, chlormadinon, amitryptyline, diclofenac, glibenclamide, simvastatin nor warfarin changes the free fraction of Tamsulosin in human plasma. Neither does Tamsulosin change the free fractions of diazepam, propranolol, trichlormethiazide, and chlormadinon. No interactions at the level of hepatic metabolism have been observed during in vitro studies with liver microsomal fractions (representative of the cytochrome P450-linked drug metabolizing enzyme system), involving amitriptyline, salbutamol, glibenclamide and Finasteride. Diclofenac and warfarin, however, may increase the elimination rate of Tamsulosin. There is a theoretical risk of enhanced hypotensive effect when given concurrently with drugs which may reduce blood pressure, including anesthetic agents and other α₁-adrenoceptor antagonists.