Tamduet Dosage/Direction for Use

Adults (including Elderly): The recommended dose of Dutasteride + Tamsulosin HCl is one capsule (500 mcg/400 mcg) once daily.
Where appropriate, Dutasteride + Tamsulosin HCl may be used to substitute concomitant Dutasteride and Tamsulosin hydrochloride in existing dual therapy to simplify treatment.
Where clinically appropriate, direct change from Dutasteride or Tamsulosin hydrochloride monotherapy to Dutasteride + Tamsulosin HCl may be considered.
Renal Impairment: The effect of renal impairment on Dutasteride + Tamsulosin HCl pharmacokinetics has not been studied. No adjustment in dosage is anticipated for patients with renal impairment.
Hepatic Impairment: The effect of hepatic impairment on Dutasteride + Tamsulosin HCl pharmacokinetics has not been studied so caution should be used in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, the use of Dutasteride + Tamsulosin HCl is contraindicated.
Pediatric Population: Dutasteride + Tamsulosin HCl is contraindicated in the pediatric population (under 18 years of age).
Method of Administration: For oral use.
Patients should be instructed to swallow the capsules whole, approximately 30 minutes after the same time of meal each day. The capsules should not be chewed or opened. Contact with the contents of the Dutasteride capsule contained within the hard-shell capsule may result in irritation of the oropharyngeal mucosa.