Tacrolimus (Tacromax) is indicated for the prophylaxis of organ rejection in patients receiving allogeneic liver, kidney, or heart transplants. It is recommended that Tacrolimus (Tacromax) be used concomitantly with adrenal corticosteroids. Because of the risk of anaphylaxis. In heart and kidney transplant recipients, it is recommended that Tacrolimus (Tacromax) be used in conjunction with azathioprine or mycophenolate mofetil. The safety and efficacy of the use of Tacrolimus (Tacromax) with sirolimus has not been established.