Spire Dosage/Direction for Use

In the treatment of edema, spironolactone is usually given in an initial oral dose of 100 mg daily, subsequently adjusted as necessary; some patients may require doses of up to 400 mg daily. In hepatic cirrhosis with ascites and edema, patients with a urinary sodium/potassium ratio greater than 1 may be given an initial dose of spironolactone 100 mg daily while patients with a ratio of less than 1 may be given initial doses of 200 to 400 mg daily.
Spironolactone is given in doses of 400 mg daily in the presumptive diagnosis of primary hyperaldosteronism; in doses of 100 to 400 mg daily for the preoperative management of hyperaldosteronism; and in the lowest effective dosage for long-term maintenance therapy in the absence of surgery.
Suggested doses of spironolactone for children range from 1 to 3 mg/kg daily, in divided doses.