The common side effects occurring during therapy with NSAIDs are generally gastrointestinal disturbances such as gastrointestinal discomfort, nausea and diarrhea; these are usually mild and reversible but in some patients, peptic ulceration and severe gastrointestinal bleeding may occur. Treatment should be discontinued if diarrhea and rashes occur. Other effects reported include drowsiness, thrombocytopenia, occasionally hemolytic anemia and rarely aplastic anemia. Convulsions are a prominent feature of overdosage with Mefenamic acid.