Probenecid prolongs the half-life of benzylpenicillin by competing with it for renal tubular secretion and may be used therapeutically for this purpose. Benzylpencillin may also interact with bacteriostatic antibacterials such as chloramphenicol and tetracyclines and may be incompatible in vitro with other drugs, including some other antibacterials. The possibility of a prolonged bleeding time after oral treatment with a broad-spectrum drug like ampicillin should be borne in mind patients receiving anticoagulants.
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