Skudexa Contraindications

Absolute Contraindications: Not to be given to those patients who have history of: Stroke: cerebrovascular accident, CVA; Uncontrolled hypertension; Coronary artery bypass graft: CABG; Congestive heart failure (CHF) NYHA II-IV.
The contraindications reported for dexketoprofen and tramadol as single agents should be taken into account.
Dexketoprofen must not be administered in the following cases: Hypersensitivity to dexketoprofen, to any other NSAID, or to any of the excipients (see Description); patients in whom substances with a similar action (e.g. acetylsalicylic acid, or other NSAIDs) precipitate attacks of asthma, bronchospasm, acute rhinitis, or cause nasal polyps, urticaria or angioneurotic oedema; known photoallergic or phototoxic reactions during treatment with ketoprofen or fibrates; patients with active peptic ulcer/gastrointestinal haemorrhage or any history of gastrointestinal bleeding ulceration or perforation; patients with history of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy; patients with chronic dyspepsia; patients who have other active bleedings or bleeding disorders; patients with Crohn's disease or ulcerative colitis; patients with severe heart failure; patients with moderate to severe renal dysfunction (creatinine clearance <59 ml/min); patients with severely impaired hepatic function (Child-Pugh C); patients with haemorrhagic diathesis and other coagulation disorders; patients with severe dehydration (caused by vomiting, diarrhoea or insufficient fluid intake).
Tramadol must not be administered in the following cases: Hypersensitivity to tramadol or to any of the excipients (see Description); in acute intoxication with alcohol, hypnotics, analgesics, opioids or psychotropic medicinal products; in patients receiving MAO inhibitors, or who have taken them within the last 14 days (see Interactions); in patients with epilepsy not adequately controlled by treatment (see Precautions); Severe respiratory depression. Tramadol/Dexketoprofen (Skudexa) is contraindicated during pregnancy and lactation (see Use in Pregnancy & Lactation).