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Sitagliptin phosphate + Metformin HCl is contraindicated in patients with: Severe renal impairment, (eGFR <30 mL/min/1.73 m2).
Known hypersensitivity to Metformin HCl, Sitagliptin phosphate or any other component.
Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma.
Sitagliptin phosphate + Metformin HCl should be temporarily discontinued in patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials, because the use of such products may result in acute alteration of renal function.
