Simeco Drug Interactions

The concurrent use of the product with tetracyclines may inhibit their absorption (except for Doxycycline and possibly minocycline). The absorption of other medicines (anticholinergics, cimetidine, isoniazid, triazole antifungals iron salts, carbenoxolone, digitoxin, quinidine, phenobarbital) may also be delayed or reduced, or warfarin and phenindione absorption may be impaired.
The concurrent use of this product with the following agents decreases their effect: Benzodiazepines, captopril, corticosteroids, fluoroquinolones, H₂ histamine receptor antagonists, hydantoins, ketoconazole, penicillamine, phenothiazines, salicylates and ticlopidine.
On the contrary, the concurrent use of this product with the following agents increases their effect: Levodopa, sulfonylureas and sodium valproate.
Acetate salts increase the adsorption and hence the toxicity of aluminum ions. With the ion-exchange resin, sodium polystyrene sulfonate, it may cause metabolic alkalosis in patients with renal failure. Antacids should not be administered in combination with the above products. These other medical products should be taken at least 1 to 2 hours before the antacids.