Safebo Mechanism of Action

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Full Prescribing Info

Action

Pharmacology: Pharmacokinetics: Bosentan is absorbed from the gastrointestinal tract with an absolute bioavailability of about 50%. Peak plasma concentrations occur about 3 to 5 hours after an oral dose. It is more than 98% bound to plasma proteins, mainly to albumin. Bosentan is metabolised in the liver by the cytochrome P450 isoenzymes CYP2C9 and CYP3A4 and is an inducer of these enzymes and possibly also of CYP2C19; after multiple dosing, plasma concentrations of bosentan decrease gradually to 50% to 65% of those seen after a single dose. Bosentan has three metabolites, one of which is active. Bosentan is excreted almost entirely as metabolites in the bile; less than 3% of an oral dose is excreted in the urine. The terminal elimination half-life is about 5 hours.

bosentan

Manufacturer:

MSN Lab

Distributor:

Stangen Pharmaceuticals

Marketer:

Mc Graw Pharma