Each vial contains: Esomeprazole Sodium eq. to Esomeprazole 40 mg.
Each ampoule contains: Sodium Chloride Injection 0.9% 10 mL.
Esomeprazole is the S-isomer of omeprazole and reduces gastric acid secretion through a specific targeted mechanism of action. It is a specific inhibitor of the acid pump in the parietal cell. Both the R- and S-isomer of omeprazole have similar pharmacodynamic activity.
Pharmacology: Pharmacodynamics: Mechanism of Action: Esomeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the secretory canaliculi of the parietal cell, where it inhibits the enzyme H+K+-ATPase C the acid pump and inhibits both basal and stimulated acid secretion.
Treatment of peptic ulcer disease, NSAID associated ulceration, gastroesophageal reflux disease and Zollinger-Ellison syndrome.
The recommended adult dose of Esomeprazole I.V is either 20 or 40 mg given once daily by intravenous injection (no less than 3 minutes) or intravenous infusion (10 to 30 minutes). Esomeprazole I.V. should not be administered concomitantly with any other medications through the same intravenous site and or tubing. The intravenous line should always be flushed with either 0.9% Sodium Chloride Injection, USP, Lactated Ringer's Injection, USP or 5% Dextrose Injection, USP both prior to and after administration of Esomeprazole I.V. for Injection.
Esomeprazole for Injection is contraindicated in patients with known hypersensitivity to the formulation.
Do not use Esomeprazole if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged. If you also take an imidazole antifungal (eg, ketoconazole), take it at least 2 hours before using Esomeprazole.
Common Side Effects: Constipation; diarrhea; dry mouth; gas; headache; nausea; pain, swelling, or redness at the injection site; stomach pain.
Severe Side Effects: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; fast heartbeat; fever, chills, or sore throat; red, swollen, blistered, or peeling skin; unusual bruising or bleeding; unusual tiredness. Seek medical attention right away if any of these severe side effects occur.
Direction for Reconstitution: Reconstitute with 10 mL of 0.9% Sodium Chloride Injection.
Store at temperatures not exceeding 30°C.
Reconstituted solution may be stored at room temperature and must be used within 24 hours from the time of initial reconstitution.
A02BC05 - esomeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
S-Omipin lyo powd for inj 40 mg
(+ 10 mL diluent amp) 1's
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