Ropenefix Dosage/Direction for Use

A dose of up to 2 g three times daily in adults and adolescents and a dose of up to 40 mg/kg three times daily in children may be particularly appropriate when treating some types of infections, such as nosocomial infections due to Pseudomonas aeruginosa or Acinetobacter spp.
Additional considerations for dosing are needed when treating patients with renal insufficiency (see further as follows).
Adults and Adolescents: See Table 2.

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Renal Impairment: The dose for adults and adolescents should be adjusted when creatinine clearance is less than 51 mL/min, as shown as follows. There are limited data to support the application of these dose adjustments for a unit dose of 2 g. (See Table 3.)

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Meropenem is cleared by hemodialysis and hemofiltration. The required dose should be administered after completion of the hemodialysis cycle.
There are no established dose recommendations for patients receiving peritoneal dialysis.
Hepatic impairment: No dose adjustment is necessary in patients with hepatic impairment.
Dose in elderly patients: No dose adjustment is required for the elderly with normal renal function or creatinine clearance values above 50 mL/min.
Pediatric population: Children under 3 months of age: The safety and efficacy of Meropenem in children under 3 months of age have not been established and the optimal dose regimen has not been identified. However, limited pharmacokinetic data suggest that 20 mg/kg every 8 hours may be an appropriate regimen.
Children from 3 months to 11 years of age and up to 50 kg body weight: The recommended dose regimens are shown in the table as follows: See Table 4.

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Children over 50 kg body weight: The adult dose should be administered.
There is no experience in children with renal impairment.