Adult Mild to moderate acute bacterial exacerbation of COPD, pneumonia, pharyngitis, tonsillitis & uncomplicated skin & skin structure infection 500 mg on the 1st day followed by 250 mg once daily on day 2-5. Typhoid fever 1 g on day 1, then 500 mg for the next 6 days. Or 1 g once daily for 5 days. Genital ulcer disease 1,000 mg single dose. Urethritis & cervicitis 2,000 mg single dose. Childn Pharyngitis/tonsillitis 12 mg/kg once a day for 5 days (max 500 mg/day). Typhoid/enteric fever 20 mg/kg once daily for 5 days. Childn >6 mth Acute otitis media & community-acquired pneumonia 10 mg/kg as a single dose on the 1st day followed by 5 mg/kg on days 2-5 (max 500 mg/day).
Should be taken at least 1 hr before or 2 hr after taking antacids. Avoid concomitant ergot derivatives. Caution when co-administered w/ digoxin & cyclosporin.
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