Hypotension w/ other antihypertensive agents. Not recommended in combination w/ α-receptor blockers. May increased hypertensive effect w/ vasodilators & nitrates. Symptomatic hypotension w/ PDE-5 inhibitors (eg, sildenafil, tadalafil & vardenafil). May reduce antihypertensive effect w/ sympathomimetics. My reduce BP & vascular reactions to dopamine, ephedrine, epinephrine, metaraminol, methoxamine & phenylephrine. May influence renin activity & urinary excretion of vanillylmandelic acid. Reduced hypertensive effect of clonidine IV.