RiteMED Simvastatin Dosage/Direction for Use

The patient should be placed on a standard cholesterol-lowering diet before receiving simvastatin and should continue on this diet during treatment with Simvastatin.
Coronary Heart Disease: Initial Dose: 20 mg once daily at bedtime.
May be increased at intervals of not less than 4 weeks to a maximum of 80 mg once daily given as a single dose at bedtime.
Hyperlipidemia: Initial Dose: 20 mg once daily at bedtime.
Patients who require only a moderate reduction of LDL-C may be started at 10 mg once daily at bedtime.
Homozygous Familial Hypercholesterolemia: Initial Dose: 40 mg once daily at bedtime or 80 mg/day in 3 divided doses of 20, 20 and 40 mg given in the morning, afternoon and evening, respectively.
Renal Insufficiency: Initial Dose: 5 mg once daily at bedtime with close monitoring.
Initiating therapy in patients with severe renal insufficiency (creatinine clearance <30 mL/min) at a dose above 10 mg/day should be considered carefully and implemented cautiously.
Dose modification should not be necessary in patients with mild to moderate renal impairment because simvastatin does not undergo substantial renal excretion.
Or as prescribed by a physician.