RiteMED Metoprolol Adverse Reactions

Cardiovascular: Arterial insufficiency (e.g., Raynaud's phenomenon), bradycardia, cold extremities, cardiac arrhythmias, cardiac conduction disorders, chest pain, claudication, congestive heart failure, decreased high-density lipoprotein (HDL), edema, first-degree heart block, gangrene in patients with pre-existing severe peripheral circulatory disorders (rare), hypotension, increased triglycerides, orthostatic hypotension occasionally with syncope, palpitations, peripheral edema, precordial pain, second- or third-degree heart block.
Endocrine/Metabolic: Decreased libido, hypoglycemia, unstable diabetes, weight gain; Increases in the following: alkaline phosphatase, transaminases, lactate dehydrogenase, blood urea nitrogen (BUN), serum creatinine, uric acid.
Gastrointestinal: Abdominal pain, constipation, diarrhea, digestive tract disorders, dry mouth, flatulence, gastric pain, heartburn, hepatitis (rare), hiccups, jaundice (rare), nausea, non-specific hepatic dysfunction (rare), retroperitoneal fibrosis, vomiting, xerostomia.
Musculoskeletal: Arthritis, general weakness, muscle cramps, musculoskeletal pain, polymyalgia-like syndrome, restless legs.
Nervous: Confusion, decreased alertness, depression, dizziness, full headedness, hallucination, headache, impotence, increased dreaming, insomnia, lethargy, mental confusion, nervousness, nightmares, paresthesia, personality disorder, short-term memory loss, sleep disturbances, somnolence, tiredness, vertigo.
Respiratory: Bronchospasm, dyspnea, rhinitis, shortness of breath, wheezing.
Skin: Alopecia, dry skin, hyperhidrosis, photosensitivity (very rare), pruritus, rash, sweating, worsening of psoriasis (very rare).
Special senses: Blurred vision, dry eyes, eye irritation, hearing disorders (e.g., hypoacusis or deafness), tinnitus, visual disturbances.
Others: Peyronie's disease, agranulocytosis, fatigue, increased or decreased antinuclear factor (ANF) levels, lassitude, thrombocytopenia.
Potential Undesirable Effects: Cardiovascular: Intensification of AV block.
Hematologic: Eosinophilia, nonthrombocytopenic purpura, thrombocytopenic purpura.
Hypersensitivity reactions: Erythematous rash, fever combined with aching and sore throat, laryngospasm, respiratory distress.
Nervous: Reversible mental depression progressing to catatonia, acute reversible syndrome characterized by disorientation to time and place, emotional lability, slightly clouded sensorium, decreased performance on neuropyschometrics.