RiteMED Metformin Extended-Release Tablet 1 g Use In Pregnancy & Lactation

Pregnancy: Uncontrolled hyperglycemia in the periconceptional phase and during pregnancy is associated with increased risk of congenital abnormalities, pregnancy loss, pregnancy-induced hypertension, preeclampsia and perinatal mortality. Maintaining blood glucose levels as close to normal as possible is necessary during pregnancy since abnormal blood glucose levels are associated with a higher incidence of congenital abnormalities. Insulin is recommended during pregnancy.
Metformin crosses the placenta with levels that can be as high as maternal concentrations.
If clinically needed, the use of metformin can be considered during pregnancy and in the periconceptional phase as an addition or an alternative to insulin.
Lactation: Metformin is excreted into human milk. However, as only limited data are available, breastfeeding is not recommended during metformin treatment. The importance of metformin to the mother should be considered when deciding whether to discontinue breastfeeding or to discontinue metformin because the potential for hypoglycemia in breastfeeding infants may exist. Consider insulin therapy for adequate glycemic control if metformin is discontinued.