RiteMED Meloxicam Overdosage

There is limited experience with meloxicam overdose.
Acute NSAID overdosage may present with symptoms including lethargy, drowsiness, nausea, vomiting, and epigastric pain. These symptoms are usually reversible with supportive care. Gastrointestinal bleeding may occur. Severe poisoning may result in hypertension, acute renal failure, hepatic dysfunction, respiratory depression, coma, convulsions, cardiovascular collapse, and cardiac arrest. Anaphylactoid reactions may also occur.
Manage patients with symptomatic and supportive care following overdosage with an NSAID. Gastric lavage followed by activated charcoal is recommended in acute overdosage but gastric lavage performed more than one hour after an overdose has little benefit. Activated charcoal is recommended in patients who present one to two hours after overdose. Administer activated charcoal repeatedly in substantial overdose or severely symptomatic patients. Removal of Meloxicam is accelerated with 4 g oral doses of cholestyramine given thrice daily. Meloxicam is highly protein bound. Thus, forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion may not be useful.