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Clinical features of acute overdosage of levofloxacin may include CNS symptoms such as confusion, dizziness, impairment of consciousness, and convulsive seizures, increases in QT interval as well as GI reactions such as nausea and mucosal erosions.
CNS effects including hallucination and tremor have been observed in post marketing experience.
In the event of overdose, symptomatic treatment should be implemented. The patient should be observed and proper hydration maintained. ECG monitoring should be undertaken because of the possibility of QT interval prolongation.
The administration of activated charcoal as soon as possible after oral overdose may prevent excessive increase of systemic levofloxacin exposure. Antacids may be used for protection of the gastric mucosa.
Hemodialysis, including peritoneal dialysis and CAPD, are not effective in removing levofloxacin from the body. No specific antidote exists.
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