May be administered with other antihypertensive agents.
May be taken with or without food. (See table.)

Dosage in elderly (>75 years old): Dosage adjustment is not usually necessary although consider giving an initial dose of 75 mg once a day.
Dosage in patients with hepatic impairment: No dosage adjustment is necessary in patients with mild to moderate hepatic impairment. There is no clinical experience in patients with severe hepatic impairment.
Dosage in patients with renal impairment: No dosage adjustment is necessary.
Dosage in volume- and salt-depleted patients (e.g., patients treated vigorously with diuretics or on hemodialysis): Initial Dose: 75 mg once a day.