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Diphenhydramine can cause marked drowsiness; it severely impairs driving performance in standard off the road tests. Patients should avoid driving or performing other tasks requiring complete mental alertness within 8 hours of ingestion.
Diphenhydramine should not be taken with other antihistamines, sedatives or tranquilizers except on medical advice.
Patients should be advised to avoid alcoholic beverages while taking this product. Alcohol potentiates the sedative effects of diphenhydramine.
Patients should be advised to avoid using diphenhydramine for self-medication for longer than 7 to 10 nights and to consult a physician if insomnia persists continuously for longer than two weeks because insomnia may be indicative of a serious underlying physical, emotional, or psychological condition requiring medical attention.
Do not use with any other product containing diphenhydramine, including topical formulations.
Caution should be exercised if given to patients with liver disease (the terminal half-life of diphenhydramine may be prolonged in cirrhotic patients), glaucoma, urinary retention, myasthenia gravis, seizure disorders, hyperthyroidism, cardiovascular disease, or hypertension.
Use in Children: As in adults, antihistamines may diminish mental alertness in children. In the young child, particularly, they may produce excitation.
Use in Elderly: Antihistamines are more likely to cause dizziness, sedation and hypotension in elderly patients.
