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Penicillinase-resistant penicillins eg, cloxacillin are physically and/or chemically incompatible with aminoglycosides and can inactivate the drugs in vitro. If concomitant therapy is indicated, avoid in vitro mixing of penicillinase-resistant penicillins and aminoglycosides and administer drugs separately. Penicillinase-resistant penicillins can also inactivate aminoglycosides in vitro in serum samples obtained from patients receiving concomitant therapy with the drugs. This could adversely affect results of serum aminoglycoside assays performed on the serum samples.
Laboratory Test Interactions: Studies using cloxacillin indicate that cloxacillin causes false-positive or falsely elevated results in turbidimetric methods for urinary and serum proteins that use sulfosalicylic acid or trichloroacetic acid.
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