Sign Out
Usual Recommended Adult Dose: See Table 3.
Click on icon to see table/diagram/imageUsual Dose for Non-Mycobacterial Infections in Children 7 Years and Older (Who can swallow tablet whole): 250 mg every 12 hours for 5 to 10 days depending on the type and severity of infection. Or as prescribed by a physician.
Dosage in Patients with Renal Impairment (with creatinine clearance less than 30 mL/min): See Table 4.
Click on icon to see table/diagram/imageSuspension: Clarithromycin granules (clarithromycin for oral suspension, USP) may be given with or without food.
Children: The usual recommended daily dosage is 15 mg/kg/day divided every 12 hours for 10 days. Clarithromycin may be administered without dosage adjustment in the presence of hepatic impairment if there is normal renal function. However, in the presence of severe renal impairment with or without coexisting hepatic impairment, the dose should be halved or the dosing interval doubled.
Pediatric Dosage Guidelines: (See Table 5.)
Click on icon to see table/diagram/imageMycobacterial Infection: Prophylaxis: The recommended dose of clarithromycin for the prevention of disseminated Mycobacterium avium disease is 500 mg b.i.d. In children, the recommended dose is 7.5 mg/kg b.i.d. No studies of clarithromycin for MAC prophylaxis have been performed in pediatric populations and the doses recommended for prophylaxis are derived from MAC treatment studies in children.
Treatment: Clarithromycin is recommended as the primary agent for the treatment of disseminated infection due to Mycobacterium avium complex. Clarithromycin should be used in combination with other antimycobacterial drugs that have shown in vitro activity against MAC or clinical benefit in MAC treatment. The recommended dose for mycobacterial infections in adults is 500 mg b.i.d. In children, the recommended dose is 7.5 mg/kg b.i.d. Clarithromycin therapy should continue for life if clinical and mycobacterial improvements are observed.
Constituting instructions: Add half volume of water to the bottle and shake vigorously. Add the remainder of water to the bottle and shake. Shake well before each use. Oversize bottle provides shake space. Keep tightly closed. Do not refrigerate. After mixing, store at 15° to 30°C and use within 14 days.
Pediatric use: Safety and effectiveness of clarithromycin in pediatric patients under 6 months of age have been established. The safety of clarithromycin has not been studied in MAC patients under the age of 20 months. Neonatal and juvenile animals tolerated clarithromycin in a matter similar to adult animals. Young animals were slightly more intolerant to acute overdosage and to subtle reductions in erythrocytes, platelets and leukocytes but were less sensitive to toxicity in the liver, kidney, thymus, and genitalia. Clarithromycin tablets and oral suspension can be taken with or without food and can be taken with milk; however, do not refrigerate the suspension.
