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Symptoms: No specific information is available on the treatment of overdosage with Alendronate. Overdosage with bisphosphonates would be likely to result in symptoms of hypocalcemia, paresthesia, hypotension, fever and vomiting and upper gastrointestinal adverse events, such as upset stomach, heartburn, esophagitis, gastritis, or ulcer, may result from oral overdosage.
Treatment: If necessary, parenteral infusion of a calcium salt could be given. Giving milk or antacids, to bind the bisphosphonate and minimize absorption, has been suggested for oral overdosage. Due to the risk of esophageal irritation, vomiting should not be induced and the patient should remain fully upright.
Decontamination: Activated charcoal, gastric lavage.
