Rhea Amoxicillin Drug Interactions

Probenecid decreases the renal tubular secretion of Amoxicillin. Concomitant use with Amoxicillin may result in increased and prolonged blood levels of Amoxicillin.
In common with other antibiotics, Amoxicillin may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives.
Concurrent administration of allopurinol during treatment with Amoxicillin can increase the likelihood of allergic skin reactions. It is recommended that when testing for the presence of glucose in urine during Amoxicillin treatment, enzymatic glucose oxidase methods should be used. Due to the high urinary concentrations of Amoxicillin, false positive readings are common with chemical methods.
In the literature there are rare cases of increased international normalised ratio in patients maintained on acenocoumarol or warfarin and prescribed a course of Amoxicillin. If co-administration is necessary, the prothrombin time or international normalised ratio should be carefully monitored with the addition or withdrawal of Amoxicillin.