The pharmacological side effects of Salmeterol treatments such as tremor, subjective palpitations and headache, have been reported, but tend to be transient and reduce with regular therapy. Cardiac arrhythmias may occur, usually in susceptible patients. Systemic effects may occur with any inhaled corticosteroid. Possible systemic effects include Cushing's syndrome, Cushingoid features, adrenal suppression, decrease in bone mineral density, cataract and glaucoma and more rarely, a range of psychological or behavioural effects including psychomotor hyperactivity, sleep disorders, anxiety, depression or aggression.
In case of Fluticasone Propionate, hoarseness and candidiasis (thrush) of the mouth and throat can occur in some patients. Gargling with water after use of Rezpira HFA Inhalation Aerosol may relieve both hoarseness and incidence of candidiasis.