Overdosage of Paracetamol usually involves 4 phases with the following signs and symptoms: Eating disorder, nausea, vomiting, malaise and excessive sweating;
Right upper abdominal pain or tenderness, liver enlargement which may be characterized by abdominal discomfort of "feeling full", elevated bilirubin and liver enzyme concentration, prolongation of prothrombin time, and occasionally decreased urine output;
Eating disorder, nausea, vomiting, and malaise recur and signs of liver (e.g., jaundice) and possibly kidney failure; IV. Recovery or progression to fatal complete liver failure;
Signs of acute overdose of Caffeine include vomit similar to ground of coffee, frequent urination, increased heart rate, tremors and convulsion. Metabolic acidosis, ketosis and hyperglycemia have also been reported.
Chronic intake of 500mg of Caffeine a day may be associated with caffeinism, a symptom of low grade irregular fever, difficulty in sleeping, anorexia, anxiety, and irritability.
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