Ca-4-methyl-2-oxovalerate (α-ketoanalogue of leucine, Ca salt) 303 mg, Ca-3-methyl-2-oxobutyrate (α-ketoanalogue of valine, Ca salt) 258 mg, Ca-2-oxo-3-phenylpropionate (α-ketoanalogue of phenylalanine, Ca salt) 204 mg, Ca-3-methyl-2-oxovalerate (α-ketoanalogue of isoleucine, Ca salt) 201 mg, Ca-DL-2-hydroxy-4-(methylthio)-butyrate (α-hydroxy analogue of methionine, Ca salt) 177 mg, L-lysine acetate 315 mg, L-threonine 159 mg, L-histidine 114 mg, L-tyrosine 90 mg, L-tryptophan 69 mg. Total nitrogen content 108 mg, Ca 3.75 mmoL (150 mg)
Indications/Uses
Prevention & therapy of damages due to faulty/deficient protein metabolism in chronic renal insufficiency in connection w/ limited protein in food: 40 g daily (for adults) & less (ie, in patients w/ GFR <25 mL/min or between 5-15 mL/min).
Regularly monitor serum Ca levels. Monitor for reduced levels of serum phosphate. Ensure adequate supply of cal. No experience for use during pregnancy & lactation, & in ped patients.
May increase serum Ca level w/ Ca-containing products (eg, acetolyte). Reduce dose of Al hydroxide, as appropriate, due to improved uremic symptoms during therapy. Observe at least 2 hr interval between administration of Renalog Max & drugs which form poorly soluble compd w/ Ca [eg, tetracyclines, quinolones (eg, ciprofloxacin & norfloxacin), prep containing Fe, fluoride & estramustin]. In case of hypercalcaemia, increased sensitivity to drugs which increase heart action (eg, cardiac glycosides).
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