Hypersensitivity to the active substance or to any of the excipients; Active peptic ulceration or active gastro-intestinal (GI) bleeding; Patients who, after taking acetylsalicylic acid or NSAIDs including COX-2 (cyclooxygenase-2) inhibitors, experience bronchospasm, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria, or allergic-type reactions; Pregnancy and lactation (see Use in Pregnancy & Lactation); Severe hepatic dysfunction (serum albumin <25 g/L or Child-Pugh score ≥10); Estimated renal creatinine clearance <30 mL/min; Children and adolescents under 16 years of age; Inflammatory bowel disease; Congestive heart failure (NYHA II-IV); Patients with hypertension whose blood pressure is persistently elevated above 140/90 mmHg and has not been adequately controlled; Established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease.