Ranvast Mechanism of Action

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Full Prescribing Info

Action

Pharmacology: Pharmacokinetics: Atorvastatin is rapidly absorbed from the gastro-intestinal tract. It has low absolute bioavailability of about 12% due to presystemic clearance in the gastro-intestinal mucosa and/or first-pass metabolism in the liver, its primary site of action. Atorvastatin is metabolized by cytochrome P450 3A4 to a number of compounds which are also active inhibitors of HMG-CoA reductase. The mean plasma elimination half-life of atorvastatin is about 14 hours although the half-life of inhibitory activity for HMG-CoA reductase is approxiamately 20 to 30 hours due to the contribution of the active metabolites. It is 98% bound to plasma proteins. Atorvastatin is excreted as metabolites, primarily in the bile.

atorvastatin

Manufacturer:

Centurion Lab

Distributor:

Philgen