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Ethambutol: Patients with known optic neuritis unless clinical judgement determines that it may be used.
Pyrazinamide: Patients should have baseline serum uric acid and liver function determinations. Patients with preexisting liver disease or those patients at increased risk for drug-related hepatitis (eg, alcohol abusers) should be followed closely. Because it contains pyrazinamide, Quadmax should be discontinued and not be resumed if signs of hepatocellular damage or hyperuricemia accompanied by an acute gouty arthritis appear. If hyperuricemia accompanied by an acute gouty arthritis occurs without liver dysfunction, the patient should be transferred to a regimen not containing pyrazinamide.
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