Per 2.5 mL of Pulmodual soln for inhalation Ipratropium Br 500 mcg, salbutamol sulfate 2.5 mg. Per actuation of Pulmodual MDI Ipratropium Br 20 mcg, salbutamol sulphate 100 mcg
Indications/Uses
Pulmodual Reversible airways obstruction eg, asthma & COPD for patients in need of more than a single bronchodilator or who require 2nd bronchodilator. Pulmodual MDI Relief & prevention of asthma & asthmatic symptoms.
PulmodualAdult & adolescent >12 yr 2.5 mL every 6-8 hr. Acute attacks 2.5 mL is sufficient for the prompt relief of symptom. Severe cases 5 mL if attack has not been relieved by 2.5 mL. Childn 2-12 yr 3 drops/kg/dose every 6-8 hr. Max: 2.5 mg of salbutamol. Elderly Adult dose. Pulmodual MDI 2 inhalations qid. Max dose of 12 inhalations in 24 hr.
Hypersensitivity to ipratropium Br, salbutamol or to atropine or its derivatives. Pulmodual Hypertrophic obstructive cardiomyopathy or tachyarrhythmia.
Paradoxical bronchospasm; patients w/ CV disorders especially coronary insufficiency, cardiac arrhythmias & HTN; cardiac arrest following an unexpected development of a severe acute asthmatic crisis & subsequent hypoxia; immediate hypersensitivity reactions; narrow-angle glaucoma, prostatic hyperplasia or bladder-neck obstruction; history of diabetes, heart disease (eg, irregular heart beat, coronary insufficiency), high BP, glaucoma, hypokalemia, seizure, hyperthyroidism, urination problems (eg, enlarged prostate, urinary retention). Hepatic or renal insufficiency. Do not drive, use machinery or do any activity that requires alertness or clear vision. Limit alcohol beverages. Pregnancy & lactation.
Additive interaction w/ anticholinergic agents. Increased risk of adverse CV effects w/ β-adrenergic agents. Salbutamol: Inhibits the effect of each other w/ β-receptor blocking agents, caution in patients w/ hyperreactive airways. Possibly may reduce plasma conc of digoxin. Increased risk of hypokalemia w/ diuretics (eg, loop or thiazide diuretics) & theophylline (high-dose). May potentiate action on CVS w/ MAOIs or TCAs.
R03AL02 - salbutamol and ipratropium bromide ; Belongs to the class of combination of adrenergics with anticholinergics, that may also include a corticosteroid. Used in the treatment of obstructive airway diseases.
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