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Overdosage of tamsulosin HCl may lead to hypotension. Provide cardiovascular support immediately. Keeping the patient in supine position may help restore blood pressure and normalize heart rate. Consider administration of intravenous fluids if this measure is inadequate. Use vasopressors if necessary and monitor and support renal function as needed. Dialysis is unlikely to be of benefit since tamsulosin is 94% to 99% protein bound.
Tamsulosin's absorption may be impeded by emesis. Gastric lavage, activated charcoal and an osmotic laxative may be useful when large quantities are involved.
Severe headache that resolved on the same day was reported in one patient with an overdose of about 12 mg of tamsulosin HCl. Acute overdose with tamsulosin HCl leading to acute hypotension (systolic blood pressure 70 mmHg), vomiting and diarrhea has been observed at a dose of 5 mg. The patient was given fluid replacement therapy and was discharged on the same day.
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